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meta|Evidence - COVID-19

Living meta-analysis and evidence synthesis of therapies for COVID19  

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Treament Trials   auto
deathsclinical improvementdeath or ventilation
0---
7 / 16 0.91 [0.70; 1.19], 5 RCTs, I2=0%
inconclusive result		 0.71 [0.37; 1.35], 1 RCT, I2=0%
inconclusive result
1 1.10 [0.49; 2.45], 1 RCT, I2=0%
inconclusive result		 1.23 [0.87; 1.74], 1 RCT, I2=0%
inconclusive result		-
11 / 18 0.91 [0.71; 1.15], 11 RCTs, I2=12%
inconclusive result		 1.16 [0.87; 1.56], 6 RCTs, I2=54%
inconclusive result		-
1 / 2 0.54 [0.31; 0.95], 1 RCT, I2=0%
unassessable degree of certainty		 2.87 [1.12; 7.36], 1 RCT, I2=0%
unassessable degree of certainty		-
1 / 2 --
0---
0---
4 / 5 0.58 [0.25; 1.37], 4 RCTs, I2=34%
inconclusive result		 1.40 [0.61; 3.23], 2 RCTs, I2=79%
inconclusive result		-
8 / 18 0.94 [0.72; 1.23], 7 RCTs, I2=29%
safety concern
inconclusive result		 1.44 [1.06; 1.96], 2 RCTs, I2=44% conclusive
moderate degree of certainty		 0.96 [0.65; 1.43], 3 RCTs, I2=26%
inconclusive result
3 / 6 1.09 [0.56; 2.12], 2 RCTs, I2=0%
inconclusive result		 1.03 [0.75; 1.41], 1 RCT, I2=0%
inconclusive result		-
2 1.08 [0.85; 1.38], 1 RCT, I2=0%
inconclusive result		 0.83 [0.67; 1.03], 1 RCT, I2=0%
inconclusive result		-
1 1.09 [0.78; 1.53], 1 RCT, I2=0%
inconclusive result		--

Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant

149
treatments 		  718
studies with results 		  1743
studies screend 		  1629
references

This project is supported by a grant of the French Ministry of Health (Hospital Clinical Research Program, PHRC-N), Université de Lyon (UdL/Idex), and self-funded by Hospices Civils de Lyon, CNRS UMR5558 LBBE University Lyon-1.

     

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